The aim of present investigation was to develop dissolution method for evaluation of metoclopramide tablet. Different dissolution condition such as type of USP apparatus, speed of rotation of paddle and pH of dissolution medium were evaluated. The best in-vitro conditions obtained with phosphate buffer having pH 6.8 as a dissolution medium, USP Type II apparatus and 50 rpm speed were found to be most satisfactory. The release of drug analysed by using UV-visible spectrophotometric method which had regression coefficient 0.999 at concentration range 5-25 ppm. The dissolution test developed was adequate for its longer discriminative capacity in the release characteristic of product and could be applied for in-vitro evaluation of metoclopramide tablet.
Loading....